• 17 alpha hydroxylase In this study significant reduction in

  2025-02-18

  

  In this study, significant reduction in the HCO3− content in sham-operated and testosterone-treated rats following bafilomycin A1 administration suggested that V-ATPase could be involved in mediating the decrease in vas deferens fluid HCO3− content, most probably due to the increase in H+ secretion

• Human leukemic blasts from both AML

  2025-02-18

  

  Human leukemic blasts from both AML and ALL patients demonstrated 5-, 12-, and 15-LOX expression [54]; however, using quantitative PCR, 5-LOX was much more prevalent than 15-LOX. When 15-HETE, 12-HETE, and LTB4 were tested for a direct effect on leukemic blasts, none induced apoptosis [54]. In contr

• Several studies have demonstrated that depletion of

  2025-02-18

  

  Several studies have demonstrated that depletion of functional ATR increases the sensitivity of cancer cells to oncogene-induced replication stress thereby hindering tumour growth and inducing extensive cell death (Gilad et al., 2010, Murga et al., 2011, Schoppy et al., 2012). Importantly, Schoppy e

• ep4 antagonist Secondly leptin has been shown to enhance aro

  2025-02-18

  

  Secondly, leptin has been shown to enhance aromatase mRNA expression, aromatase content and its enzymatic activity in epithelial breast cancer ep4 antagonist by inducing promoters II and I.3 via an enhanced binding of transcription activator protein 1 (AP-1) complex to specific DNA sites in the pro

• br Emerging Vascular Mechanisms of AA Therapy Resistance Exp

  2025-02-18

  

  Emerging Vascular Mechanisms of AA Therapy Resistance Experimental and clinical evidence indicates that physiological angiogenesis generates blood vessels capable of restoring perfusion [1], whereas tumoral angiogenesis gives rise to vessels that are structurally and functionally abnormal, therei

• br Conclusion These studies broadly demonstrate

  2025-02-18

  

  Conclusion These studies broadly demonstrate that dopamine and endocannabinoid signaling in the NAc can have diverse effects on AMPAR-mediated synaptic function depending on previous psychostimulant experience. Here, we examined mechanisms underlying the depotentiation of AMPAR-mediated synaptic

• The functional significance of the cap residues with

  2025-02-18

  

  The functional significance of the cap residues with regard to the established role of PfA-M1 in hemoglobin catabolism in the food vacuole is a key question that is difficult to address with in vitro studies. We note that three of the dipeptide substrates used in our study are found in the sequences

• A unique finding in this

  2025-02-18

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic 2'-O-Methyl-ATP for substrate, can regulate CREB phosphoryation in the context of Alzhe

• br Introduction Psychostimulant abuse and addiction

  2025-02-17

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

• A clear link between ADR stimulation and decreased respirati

  2025-02-17

  

  A clear link between α2-ADR stimulation and decreased respiration in β-cells is established and consistent with proteomics data. Current discoveries in islets have identified physical interactions between ADR-coupled G proteins and cellular components such as insulin vesicles and ion channels (Zhao

• RNA purification kit In order to get a better

  2025-02-17

  

  In order to get a better understanding of this synergy, we tested the effect of preliminary incubation of RNA purification kit with non-stimulating concentrations of gonadotropins or FSK before subsequent stimulation by FSK or gonadotropins alone, also at sub-stimulating concentrations. We observed

• Salivary amylase activity was not

  2025-02-17

  

  Salivary α-amylase activity was not significantly different between bitches with pyometra and healthy bitches, and there were no significant changes after ovariohysterectomy, similar to chromogranin A (Jitpean et al., 2015). Therefore, it is postulated that the SAM axis is not activated in bitches w

• Concanavalin A glycan binding In conclusion two novel series

  2025-02-17

  

  In conclusion, two novel series of furo[2,3-]pyrimidin4-amines and 7-pyrrolo[2,3-]pyrimidin-4-amines which exhibit potent in vitro inhibitor activity against ACK1 have been identified and evaluated. 1,3-Dithiolane-substituted pyrrolopyrimidine displays excellent ACK1 cellular inhibition, good kinase

• br Antioxidative stress and anti inflammation Oxidative stre

  2025-02-17

  

  Antioxidative stress and anti-inflammation Oxidative stress is a major cause of reduced endothelial NO bioavailability in hypertension, and inflammatory response is thought to play an important role in these processes (Blake and Ridker, 2001, Landmesser et al., 2006). Reactive oxygen species (ROS

• Tyramide Signal Amplification Kit br Material and methods br

  2025-02-17

  

  Material and methods Results Discussion Clinical gene therapy trials with viral vectors have been in use for treatment of various genetic disorders and diseases, however efficacious, targetable and highly reliable non-viral delivery systems are needed for safe and long-term applications. De

16102 records 17/1074 page Previous Next First page 上5页 1617181920 下5页 Last page